Benzoflavone supplement health benefit

In animal studies, benzoflavone has exhibited significant encouraging results in the reversal of tolerance and dependence of several addiction-prone psychotropic drugs, including morphine, nicotine, ethanol, diazepam and delta-9-tetrahydrocannabinol. The flavonoid 7,8-benzoflavone was recently identified as one of the most potent inhibitors of breast cancer resistance protein (BCRP).

Pharmacokinetics and bioavailability of the flavonoid 7,8-benzoflavone in rats.
J Pharm Sci. 2008 Oct; Wang X, Morris ME. Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, 517 Hochstetter Hall, Amherst, New York 14260, USA.
Little is known of the in vivo disposition of 7,8-benzoflavone. The objective of this study was to investigate the pharmacokinetics and bioavailability of 7,8-benzoflavone in rats. Three intravenous and three oral doses were administered to rats. The dose-normalized plasma concentration versus time curves did not superimpose with each other, indicating the nonlinear pharmacokinetics of 7,8-benzoflavone. 7,8-benzoflavone exhibited a large volume of distribution and rapid oral absorption. The bioavailability of 7,8-benzoflavone was low and dose-dependent. A pharmacokinetic model with dose-dependent bioavailability, linear absorption and nonlinear elimination best described the pharmacokinetic profiles of 7,8-benzoflavone. Using a 50 mg/kg oral dose of 7,8-benzoflavone, we could significantly increase the AUC for the breast cancer resistance protein substrate nitrofurantoin, demonstrating the potential for BCRP-mediated drug interactions.

Benzoflavone supplement questions
Q. I'm looking for a product that contains 7,8 benzoflavone, which body builders use to boost testosterone through it's anti-aromatase action. I can't find it for sale anywhere although I understand it's derived from passion flower. Can I take passion flower instead, and if so, how much to get an effective dose of benzoflavone? Also, do you have any recommendations for any product that raises testosterone, especially free testosterone?
   A. DHEA could raise testosterone levels. There is not enough benzoflavone in passion flower herb to have a significant effect.

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