Benzoflavone supplement health benefit and studies
In animal studies, benzoflavone has exhibited significant encouraging results in the reversal of tolerance and dependence of several addiction-prone psychotropic drugs, including morphine, nicotine, ethanol, diazepam and delta-9-tetrahydrocannabinol. The flavonoid 7,8-benzoflavone was recently identified as one of the most potent inhibitors of breast cancer resistance protein (BCRP).
Pharmacokinetics and bioavailability of the flavonoid 7,8-benzoflavone in rats.
J Pharm Sci. 2008 Oct;
Wang X, Morris ME.
Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical
Sciences, University at Buffalo, State University of New York, 517 Hochstetter
Hall, Amherst, New York 14260, USA.
Little is known
of the in vivo disposition of 7,8-benzoflavone. The objective of this study was
to investigate the pharmacokinetics and bioavailability of 7,8-benzoflavone in
rats. Three intravenous and three oral doses were administered to rats. The
dose-normalized plasma concentration versus time curves did not superimpose with
each other, indicating the nonlinear pharmacokinetics of 7,8-benzoflavone.
7,8-benzoflavone exhibited a large volume of distribution and rapid oral
absorption. The bioavailability of 7,8-benzoflavone was low
and dose-dependent. A pharmacokinetic model with dose-dependent
bioavailability, linear absorption and nonlinear elimination best described the
pharmacokinetic profiles of 7,8-benzoflavone. Using a 50 mg/kg oral dose of
7,8-benzoflavone, we could significantly increase the AUC for the breast cancer
resistance protein substrate
nitrofurantoin, demonstrating the potential for BCRP-mediated drug interactions.
Benzoflavone supplement questions
I'm looking for a product that contains 7,8 benzoflavone, which body builders
use to boost testosterone through it's anti-aromatase action. I can't find it
for sale anywhere although I understand it's derived from passion flower. Can I
take passion flower instead, and if so, how much to get an effective dose of
benzoflavone? Also, do you have any recommendations for any product that raises
testosterone, especially free testosterone?
DHEA hormone could raise testosterone levels. There is not enough
benzoflavone in passion flower herb to have a significant effect.
Home bilberry extract has a number of flavonoid compounds