Bergapten health benefit and research
Bergapten is found in bergamot.
Bergamot juice contains different classes of flavonoids (e.g. flavanones and flavones) that can exert beneficial effects on human health. Some of the substances in bergamot include neoeriocitrin, naringin and neohesperidin, naringin, neohesperidin and neoeriocitrin, vicenin-2, stellarin-2, rhoifolin and neodiosmin. Bergapten and bergamottin are the primary furanocoumarins in bergamot juice.
Vitiligo treatment
Psoralen and bergapten: in silico metabolism and toxicophoric analysis of drugs
used to treat vitiligo.
J Pharm Pharm Sci. 2009; da Silva VB, Kawano DF, Carvalho I, da Conceição
EC, de Freitas O, da Silva CH. Departamento de Ciências Farmacêuticas, Faculdade
de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão
Preto, CEP 14040-903, Brazil.
To discuss the contribution of psoralen and bergapten metabolites on
psoralens toxicity. Computational chemistry prediction of metabolic reactions
and toxicophoric groups based on the expert systems Derek and Meteor. A total of
15 metabolites were suggested for both psoralen and bergapten based on phase 1
and 2 biotransformations until the 3rd generation. Five toxicophoric
substructures were shared among psoralen, bergapten and their corresponding
metabolites; one toxicophoric marker (resorcinol) was only identified in
bergapten and its biotransformation products. Although the toxic effects of
psoralens are well known and documented, there is little information concerning
the role of their metabolites in this process. We believe this work add to the
knowledge of which molecular substructures are relevant to the process of
metabolism and toxicity induction, thus guiding the search and development of
more effective and less toxic drugs to treat vitiligo.
Extraction process
Comparison study of different methods for extracting
volatile oil from bergamot
Zhong Yao Cai. 2008 Aug; Medical College of Jinhua Profession and Technology
College, Jinhua 321000, China.
To test different methods for extracting volatile oil from bergamot. The
determination of bergapten was carried out by RP-HPLC. Four different ways of
organic solvent extraction, steam-input distillation, distillation of the
material mixed with water and press extraction were compared. Bergapten wasn't
extracted by ways of steam-input distillation and distillation of the material
mixed with water. The steam distillation extraction can be taken to extract
volatile oil from bergamot for protecting humans' skins.
Chemical constituents of antibacterial activity
fraction of Angelica polymorpha
Zhong Yao Cai. 2008 Aug; Hubei Key Laboratory of Natural Products Research and
Development/College of Chemistry and Life Sciences China Three Gorges
University, Yichang 443002, China.
Angelica polymorpha compounds were isolated: bisabolangelone,
isoimperatorin, oxypeucedanine, isooxypeucedanine, oxypeucedanin hydrate,
bergapten, pabulenol. Bisabolangelone is obtained from this plant for the first
time.
Bergapten is found in
Angelica polymorpha
Bergamot
Cnidium seed contains bergapten
Grapefruit juice has several furanocoumarins that inhibit P450 activity in
intestinal microsomes. These include bergamottin, bergapten, bergaptol and
6',7'-dihydroxybergamottin.
herbal extract information, benefits, side effects