Beta-asarone medical uses
Beta asarone appears to have activity against seizures. Beta asarone is found in Acorus calamus herb.
[Effects of beta-asarone on expression of FOS and GAD65
in cortex of epileptic rat induced by penicillin]
Zhong Yao Cai. 2008 Jan; The First Affiliated Hospital of Guangzhou University of TCM, Guangzhou 510405, China.
To study effects of beta-asarone on expression of FOS and GAD65 in cortex of epileptic rat induced by penicillin. The epileptic animal models were induced by penicillin. The rats were randomly divided into beta-asarone of high (100 mg/kg), medium (50 mg/kg), low (25 mg/kg) dose group, positive control group (Phenytoin sodium), negative control group (matrix). The medicine was administered orally. The effects of beta-asarone on expression of FOS and GAD65 in cortex of epileptic rat were detected by immuohistochemistry method. Beta-asarone could raise expression of FOS and reduce expression of GAD65 obviously. There were significant differences between negative control group and beta-asarone group. And it showed significant dose-effect relationship. Up-regulation of FOS may be a effective link of anti-epileptic effect of beta-asarone; reduced expression of GAD65 may be a follow-up impact of beta-asarone treatment.
Beta-asarone can increase the expression of c-fos in
epilepsy rat brain. It is an important response to epilepsy.
Beta-asarone prevents the toxicity of glutamate
[Pharmacokinetics of beta-asarone in rats]
Yao Xue Xue Bao. 2004 Oct; First Affiliated Hospital of Guangzhou University of TCM, Guangzhou 510405, China.
To study the pharmacokinetics of beta-asarone in rats. The concentration of beta-asarone in serum and organs were measured by HPLC after i.g. administration, the pharmacokinetics was analyzed with DAS software regarding the organs as independent system. The pharmacokinetics of beta-asarone can be described as first order process of one-compartment model. In the serum, T(1/2), Tpeak and Cmax were 54 min, 12 min and 3.19 mg x L(-1), respectively. The procedure in the organs was similar to that in serum. The absorption, distribution and elimination of beta-asarone are very rapid, and it is easy to pass through blood brain barrier. Brain is an important organ of distributing of beta-asarone.
Acori graminei rhizoma has a volatile oil rich in beta-asarone
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